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Maternal-Infant Research on Environmental Chemicals (The MIREC Study). Established to obtain national bio-monitoring data on pregnant women and their infants and to examine potential adverse health effects of prenatal exposure to environmental chemicals on pregnancy and infant health. Subsequently, studies of some of the MIREC children at birth, at 6 months, and at 2-5 years of age were carried out. MIREC also includes a data and bio-specimens bio-bank, for future research. We refer to this body of research as the MIREC Research Platform.
Radio-Canada International has reported, "The provincial government in New Brunswick has been spraying herbicides on 15,000 hectares of crown land since the 1970’s when it first permitted pulp and paper companies to clear-cut natural forest and replace it with plantations. The taxpayer funded programme is to benefit the lumber industry by protecting fast growing softwood trees from encroaching hardwood saplings. The hardwood saplings however are an important food supply for deer and moose, and there have been suggestions that the programme has removed thousands of tons of such food and has contributed to the steep decline in moose and deer numbers in the province in the past ten years."
Stop Spraying in NB The Canadian Press: Published Wednesday, May 18, 2016 8:47AM ADT
FREDERICTON - A group in New Brunswick says it will present a petition to members of the legislature today to protest herbicide spraying.
Persistent organic pollutants (POPs) encompass an array of anthropogenic organic and elemental substances and their degradation and metabolic by-products that have been found in the tissues of exposed animals.
As a consequence of bioaccumulation by, bio magnification of legacy and emerging, POPs are found in biota and humans. The potential biological effects of these contaminants on exposed plants, wildlife and fish and the people who harvest them are extremely important.
Highly dissolved in fat -this enables CDDs and CDFs to bio-accumulate in fatty tissues of living organisms, which results in higher levels in an individual than levels in the environment or in food The most vulnerable are the young who are exposed in-utero and post-partum (breast feeding) Although human exposure from food can be small, organochlorines do not break down easily and can build up in the body over time Affect human health at very low levels in terms of:
Contains information licenced under the GeoNB Open Data Licence
Utility Lines 1955-1972 - 17 years
Roads 1955-1973 - 18 years
Railroads 1950’s-1973 ~20 years
Tissues undergoing growth (to which cell division is important) are especially vulnerable to methylmercury, since “methylmercury is known to inhibit cell division by causing metaphase arrest,” according to a WHO publication (Sect. 9). Abnormal neuronal migration (as an effect of methylmercury exposure) is especially significant to discussion of origins of autism, since disorganization of brain cells, which could result from defective migration, was found in a 2014 study to be normally present in brains of children with ASD.
Mercury and other contaminants in common loons breeding in Atlantic Canada. Burgess NM, Evers DC, Kaplan JD. Environ. Sci. Technol. 2010
There are more than 375 mine openings at 63 separate mine sites in the Province of New Brunswick. Most of these openings are on private land. Many of them predate modern safety rules. They are dangerous! New Brunswick Energy & Resource Development
Indigenous Peoples of North America: Environmental Exposures and Reproductive Justice Indigenous American communities face disproportionate health burdens and environmental health risks compared with the average North American population. These health impacts are issues of both environmental and reproductive justice.
Human Exposure Assessment - World Health Organization
Review of Heavy Metal Effects - Agency for Toxic Substances and Disease Registry
Heavy metal pollution and human bio-toxic effects - International Journal of Physical Sciences Vol. 2 (5), pp. 112-118, May, 2007. link too... Heavy metal pollution and human bio-toxic effects
Indigenous Women and Environmental Violence
A Rights-based approach addressing impacts of Environmental Contamination on Indigenous Women, Girls and Future Generations.
‘‘Gender-benders’’: Sex and Law in the Constitution. Dayna Nadine Scott. Fem Leg Stud (2009) 17:241–265DOI 10.1007/s10691-009-9127-4.
“… there is a widespread acknowledgment of a general deterioration of male reproductive health worldwide, and many believe this can be traced to endocrine disruptors such as synthetic estrogens in the environment ….. the link between endocrine disruptors, mothers, and skewed sex ratios is this: findings show that in communities with low sex ratios there are also elevated levels of hormone-mimicking endocrine disruptors in the blood of pregnant women. …. lurking in the shadows of all of this controversy is the emerging theory of ‘feminisation’ (Mittelstaedt 2008). This posits that there might be an in utero feminisation of embryos that could have been male. The idea is that we are experiencing, not just in humans but also in animal species throughout the industrialised world, a feminisation trend that is observable across a variety of markers ...... ‘‘These things theoretically have a common etiology’’, according to Dr. Devra Davis (quoted in Mittelstaedt 2008). It is hypothesised that a declining sex ratio may be just one of a number of manifestations of a feminisation trend that is tied to endocrine disruption as very broadly experienced across the industrialised world. The gender dimension of the ‘harm’ experienced by the Aamjiwnaang community is as difficult to demonstrate as it is to dismiss. The impact of pollution seems not only to be gendered, but gendering. ...the endocrine disruptors do not just dole out their environmental health horrors disproportionately as between men and women, or girls and boys, they actually seem to be driving whether we get girls or boys. The pollution is feared to be actively producing gender. At the same time, its impact intersects directly with colonial histories of health and justice. “
Toxic chemicals blamed for the disappearance of Arctic boys.
By Daniel Howden in Nuuk, Greenland, Tuesday 11 September 2007. PREPARED FOR: Prairie Women’s Health Centre of Excellence (PWHCE) & British Columbia Centre of Excellence for Women's Health (BCCEWH) APRIL, 2009
Twice as many girls as boys are being born in remote communities north of the Arctic Circle. Across much of the northern hemisphere, particularly in the US and Japan, the gender ratio has skewed towards girls for the first time. Now scientists working with Inuit villages in Arctic Russia and Greenland have found the first direct evidence that this trend is linked to widespread chemical pollutants. Despite the Arctic's pristine environment, the area functions as a pollution sink for much of the industrialised world. Winds and rivers deliver a toxic tide from the northern hemisphere into the polar food chain.
HUMANITY AT RISK: ARE THE MALES GOING FIRST?
The Globe and Mail Sat 20 Sep 2008 Byline: Martin Mittelstaedt
Something is happening to today's boys and men: Fewer are being born compared with girls, they're having more trouble in school, virility and fertility are down and testicular cancer rates are up. Now, scientists say these 'fragile males' may be more vulnerable than females to pollutants, affecting their development as early as the womb. If so, writes Martin Mittelstaedt, it could be a bigger threat to our future than global warming.
Prenatal Exposure of Canadian Children to Polychlorinated Biphenyls and Mercury Can. J. Public Health; Vol 89; supple\;1Mmckle, G. et. al.
This article documents the exposure to environmental contaminants within subgroups of the Canadian population who are considered to be at risk as a result of the food they eat. We measured the concentrations of polychlorinated biphenyls (PCBs) and mercury in the blood drawn from the umbilical cords of newborns in various Aboriginal communities, in a coastal community and in the general population. Average concentrations of Aroclor 1260 ranged between 0.3 and 2.0 µg/L and were clearly highest among the Inuit of Nunavik and Baffin Island and among the Montagnais of Quebec. In these groups, we found contaminant levels in the blood of newborns that exceed the threshold beyond which cognitive impairments are expected to result. Average concentrations of mercury ranged between 1.0 and 14.2 µg/L; the Inuit of Nunavik and the NWT exhibited the highest exposure levels. A portion of the Nunavik and NWT Inuit had concentrations beyond the critical threshold for the appearance of neurological consequences. The variations in exposure levels resulted from the different nutritional practices of these Canadian sub-groups.
Exposure to Environmental Contaminants in Nunavik: Persistent Organic Pollutants and New Contaminants of Concern PREPARED FOR: Institute national de santé publique du Québec & Nunavik Regional Board of Health and Social Services
Many questions and hypotheses are raised regarding the sources of exposure, the influence of diet and the possible toxic effects of emerging contaminants.
Maternal and Infant Health and the Physical Environment of First Nations and Inuit Communities: A Summary Review. R. STOUT, T. DIONNE STOUT & R. HARP. PREPARED FOR Prairie Women’s Health Centre of Excellence (PWHCE)and the British Columbia Centre of Excellence for Women's Health (BCCEWH) APRIL, 2009
Relationship Between Children’s Health and Environmental Contaminant. IN: Environmental Standard Setting and Children's Health Chapter 2. The Canadian Environmental Law Association (CELA)
Although the federal government does provide some funding for research on children’s environmental health, given the significant gaps in information identified in this study and through the preceding recommendations, the government should further support Canadian research that fills those data gaps. To that end, we recommend that government-funded centres of excellence for the study of environmental health be established which would include children’s health as an important focus. Such centres should encourage collaboration and coordination of research efforts between government and universities
Domain Specific Effects of Prenatal Exposure to PCBs, Environ Health Perspect; DOI:10.1289/ehp.1206323 2014.
Multiple regression analyses revealed that higher prenatal PCB exposure was associated with decreased FTII novelty preference, indicating impaired visual recognition memory. Prenatal Hg was associated with poorer performance on A-not-B, which depends on working memory and is believed to be a precursor of executive function. Prenatal Pb was related to longer FTII fixation durations, indicating slower speed of information processing.
There is agreement that all our bodies carry heavy contaminant loads from man-made chemicals.
There is agreement that breastfeeding is indispensable for human growth and development.
There is not agreement on the health effects of contaminants in breastmilk on infants & children.
Breastfed infants are considered to be at the very top of the food chain for the simple reason that their source of nourishment is other humans, who are already at the top of the food chain.
Persistent organic pollutants (POPs) all tend to become magnified in the food chain over time.
Breastfeeding infants are thus the final target of POPs.
10 to 20 times as much of a mother's body burden of developmental toxins such as dioxins and PBDEs is transferred to the infant via the milk as by the transplacental route.
Highs, mid-levels and lows of infant exposures to certain toxins seem to correlate closely with highs, mid-levels and lows of autism or ASD traits, Publication of Pollution Action.
Initiation of breastfeeding brings a sudden, major increase in toxins ingested, compatible with abrupt later appearance of negative effects. Decline of eye contact, beginning two months after birth, was found in infants who were later diagnosed with ASD. This was not merely failure to develop, it was considered to be a derailment of initially satisfactory development.14a The study’s authors saw this to be especially significant since “deficits in eye contact have been a hallmark of autism since the condition’s initial description.
Through mechanisms, known and unknown, breastfeeding has a positive impact on child health, since breastmilk strengthens the immune system. However, heavy loads of environmental contaminants may threaten the capacity to reproduce immune-strengthening breastmilk.
Cerebellar injury seems to be the most consistent neuropathology finding among children with ASD
Contaminants in Human Milk: Weighing the Risks against the Benefits of Breastfeeding
M. Nathaniel Mead. Environ Health Perspect. 2008 Oct; 116(10): A426–A434.
Given the tendency for persistent organic pollutants (POPs), pesticides, heavy metals, and other contaminants to accumulate in human milk, researchers and parents alike are asking whether the nursling’s exposure to these pollutants might reduce or even override the health benefits.
Environmental Contaminants in Breast Milk.
Krista Nickerson, Vol. 51, Iss. 1, Jan.–Feb.2006, Pgs 26–34
Toxic environmental contaminants can be transferred from mother to infant via breastfeeding. Persistent organic pollutants (POPs) are a family of lipophilic stable chemicals that bio-accumulate in adipose tissue and create a lasting toxic body burden. Breastfeeding provides a significant source of exposure to POPs early in human life, the effects of which are unknown, and is the subject of a growing body of research. Despite the possibility of harm from environmental contaminants in breast milk, breastfeeding is still recommended as the best infant feeding method. This article reviews what is known about POPs in breast milk and their effect on infant development to inform clinicians about the issue, provide recommendations for practice, and promote environmental and public health policies that reduce human exposure to harmful pollutants.
There appears to be an extremely high correlation between hazardous infant exposures to toxins and the lactation process, which mobilizes toxins that have been stored in a mother’s body fat and excretes them to the infant in highly-concentrated form.
Exposures to neuro-developmental toxins are often extraordinarily high in the early-postnatal period, by comparison with established national or international standards and also in relation to prenatal exposures.
Publication of Pollution Action
The Children’s Environmental Health Project was designed by the Canadian Association of Physicians for the Environment (CAPE). It is intended to introduce clinicians (and their patients) to the fundamentals and broad context of children’s environmental health issues. The project also covers environmental history-taking and provides links to additional resources that may be useful to the interested individual. Lastly, a commentary is provided on the physician’s role in primary prevention of environmental health problems in children.
The Canadian Association of Physicians for the Environment (CAPE), along with its sister organization the Canadian Health and Environment Education and Research Foundation (CHEER), are the only organizations in Canada dedicated to speaking for physicians on environmental issues. CAPE does evidence-based advocacy work related to these issues, while CHEER conducts research, educates the public, and analyses policies related to environmental issues, with particular attention to their effects on human health.
The primary tenet of the Hippocratic Oath is to do no harm. The medical profession therefore fundamentally endorses a precautionary approach that strives to protect the child when there is profound uncertainty and incomplete understanding of the risks from environmental toxins.
Maternal-Infant Research on Environmental Chemicals (The MIREC Study).
Studies and reports have raised concerns about the number of chemicals in our bodies and the health effects that may be associated with the levels measured. Canadian data on this issue are limited.
This Canadian study has the following purposes:
Maternal and fetal exposure to lead, mercury, cadmium and manganese: the MIREC Study. Arbuckle TE, Liang CL, Morisset AS, Fisher M, Weiler H, Mihai Cirtiu C, Legrand M, Davis K, Ettinger AS, Fraser WD, the MIREC Study Group. Chemosphere. 2016 Nov;163:270-82. doi: 10.1016/j.chemosphere.2016.08.023. Epub 2016 Aug 16.
Given the susceptibility of the fetus to toxicants, it is important to estimate their exposure. Cd, Pb, Mn and total Hg were measured in maternal blood from the 1st and 3rd trimesters, umbilical cord blood, and infant meconium. Nutrient intakes of vitamin D, iron, and calcium (Ca) were assessed using a food frequency questionnaire and a dietary supplement questionnaire. While Cd was rarely detected in cord blood (19%) or meconium (3%), median Pb (0.77 ìg/dL), Mn (31.87 ìg/L) and Hg (0.80 ìg/L) concentrations in cord blood were significantly higher than in maternal blood. Significant negative associations were observed between estimated Ca intake and maternal Cd, Pb, Mn and Hg, as well as cord blood Pb. Vitamin D intake was associated with lower maternal Cd, Pb, and Mn as well as Pb in cord blood. Even at current metal exposure levels, increasing dietary Ca and vitamin D intake during pregnancy may be associated with lower maternal blood Pb and Cd concentrations and lower Pb in cord blood.
Maternal blood metal levels and fetal markers of metabolic function. Ashley-Martin J, Dodds L, Arbuckle TE, Ettinger AS, Shapiro GD, Fisher M, Taback S, Bouchard MF, Monnier P, Dallaire R, Fraser WD. Environmental Research. 2015;136:27-34.
This study supports the proposition that maternal levels of cadmium influence cord blood adipokine levels in a sex-dependent manner. Further investigation is required to confirm these findings and to determine how such findings at birth will translate into childhood anthropometric measures.
Air pollution exposure during pregnancy and fetal markers of metabolic function: the MIREC Study. Lavigne E, Ashley-Martin J, Dodds L, Arbuckle TE, Hystad P, Johnson M, Crouse DL, Ettinger AS, Shapiro GD, Fisher M, Morisset AS, Taback S, Bouchard MF, Sun L, Monnier P, Dallaire R, Fraser WD. American Journal of Epidemiology. 2016 2016 May 1;183(9):842-51. doi: 10.1093/aje/kwv256. Epub 2016 Mar 29.
Significant associations were seen between air pollution markers and cord blood leptin levels in models that adjusted for birth weight z score but not in models that did not adjust for birth weight z score. The roles of prenatal exposure to air pollution and fetal metabolic function in the potential development of childhood obesity should be further explored.
Concentrations of persistent organic pollutants in maternal and cord bloodfrom the maternal-infant research on environmental chemicals (MIREC) cohort study. Fisher M, Arbuckle TE, Liang CL, LeBlanc A, Gaudreau E, Foster WG, Haines D, Davis K, Fraser WD. Environmental Health. 2016 May 4;15(1):59.
Pregnant women are an especially important population to monitor for environmental exposures given the vulnerability of the developing fetus. During pregnancy and lactation chemical body burdens may change due to the significant physiological changes that occur. Developmental exposures to some persistent organic pollutants (POPs) have been linked with adverse health outcomes. Similar to other studies, we found parity, maternal age, income, education, smoking status, pre-pregnancy BMI and fish consumption to be significant predictors for most chemicals. Those participants who were foreign-born had significantly higher concentrations of organochlorinated pesticides and PCBs.